Transistor (https://transistor.fm) https://feeds.transistor.fm/podcasts-hpn-news-la-toute-premiere-chaine-de-podcasts-dedies-a-lhpn Toute première chaîne de podcasts dédiés à l'HPN proposée par le laboratoire Alexion. Vous pouvez découvrir les discussions approfondies avec les experts sur une multitude de sujets captivants : du diagnostic aux avancées thérapeutiques dans l'hémoglobinurie paroxystique nocturne. ALEXION 615c2908-c27f-50b5-817e-46f5053913ac yes fr Wed, 06 May 2026 02:41:21 -0700 Wed, 06 May 2026 02:42:27 -0700 https://img.transistorcdn.com/3RXGHOtzR10XnzorFfyWMO7tTGtEuWM_wT6IZwuefqM/rs:fill:0:0:1/w:1400/h:1400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9iYmRi/OGYzMzgyNzIwZGQ4/MWFjZjE3YTk0N2U1/ZDU1Zi5qcGc.jpg episodic ALEXION Toute première chaîne de podcasts dédiés à l'HPN proposée par le laboratoire Alexion. Vous pouvez découvrir les discussions approfondies avec les experts sur une multitude de sujets captivants : du diagnostic aux avancées thérapeutiques dans l'hémoglobinurie paroxystique nocturne. Toute première chaîne de podcasts dédiés à l'HPN proposée par le laboratoire Alexion. ALEXION No No 2 2 Dr Flore Sicre de Fontbrune - La stratégie thérapeutique pour la prise en charge de l'HPN full 9f53b5ba-9cf7-4281-8f1d-8e9e8aded288 https://share.transistor.fm/s/e3ac9104 FR/UNB-P/0200 - 1. Parker, C. et al., (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 2. Notaro, R., & Luzzatto, L. (2022). Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. New England Journal of Medicine, 387(2), 160–166. https://doi.org/10.1056/nejmra2201664 3. PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.). 4. Kulasekararaj, A. G. et al., (2023). Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. In Blood Reviews (Vol. 59). Churchill Livingstone. https://doi.org/10.1016/j.blre.2023.101041 5. Hill A, et al., (2013). Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 21: 4985-4996. 6. Kulasekararaj, A. G. et al., (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 7. Hémoglobinurie paroxystique nocturne ©Orphanet Focus Handicap / Encyclopédie Orphanet du Handicap Hémoglobinurie paroxystique nocturne Synonymes : HPN / Maladie de MarchiafavaMicheli Encyclopédie Orphanet du Handicap. (n.d.). www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORP HA447.pdf 8. Fattizzo, B. et al., (2022). Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective. In Journal of Blood Medicine (Vol. 13, pp. 327– 335). Dove Medical Press Ltd. https://doi.org/10.2147/JBM.S339660 9. Kelly, R. J. et al., (2024) Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 143, Issue 12, pp. 1157-1166. https://doi.org/10.1182/blood.2023021762 10.1182/blood.2023021762 10. Ricklin, D. et al., (2017). The renaissance of complement therapeutics. In Nature Reviews Nephrology (Vol. 14, Issue 1, pp. 26–47). Nature Publishing Group. 11. Avis du Haut Conseil de la Santé Publique en vigueur.

]]> FR/UNB-P/0200 - 1. Parker, C. et al., (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 2. Notaro, R., & Luzzatto, L. (2022). Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. New England Journal of Medicine, 387(2), 160–166. https://doi.org/10.1056/nejmra2201664 3. PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.). 4. Kulasekararaj, A. G. et al., (2023). Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. In Blood Reviews (Vol. 59). Churchill Livingstone. https://doi.org/10.1016/j.blre.2023.101041 5. Hill A, et al., (2013). Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 21: 4985-4996. 6. Kulasekararaj, A. G. et al., (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 7. Hémoglobinurie paroxystique nocturne ©Orphanet Focus Handicap / Encyclopédie Orphanet du Handicap Hémoglobinurie paroxystique nocturne Synonymes : HPN / Maladie de MarchiafavaMicheli Encyclopédie Orphanet du Handicap. (n.d.). www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORP HA447.pdf 8. Fattizzo, B. et al., (2022). Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective. In Journal of Blood Medicine (Vol. 13, pp. 327– 335). Dove Medical Press Ltd. https://doi.org/10.2147/JBM.S339660 9. Kelly, R. J. et al., (2024) Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 143, Issue 12, pp. 1157-1166. https://doi.org/10.1182/blood.2023021762 10.1182/blood.2023021762 10. Ricklin, D. et al., (2017). The renaissance of complement therapeutics. In Nature Reviews Nephrology (Vol. 14, Issue 1, pp. 26–47). Nature Publishing Group. 11. Avis du Haut Conseil de la Santé Publique en vigueur.

]]> Mon, 05 Jan 2026 07:59:35 -0800 Alexion Alexion 598 FR/UNB-P/0200 - 1. Parker, C. et al., (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 2. Notaro, R., & Luzzatto, L. (2022). Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. New England Journal of Medicine, 387(2), 160–166. https://doi.org/10.1056/nejmra2201664 3. PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.). 4. Kulasekararaj, A. G. et al., (2023). Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. In Blood Reviews (Vol. 59). Churchill Livingstone. https://doi.org/10.1016/j.blre.2023.101041 5. Hill A, et al., (2013). Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 21: 4985-4996. 6. Kulasekararaj, A. G. et al., (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 7. Hémoglobinurie paroxystique nocturne ©Orphanet Focus Handicap / Encyclopédie Orphanet du Handicap Hémoglobinurie paroxystique nocturne Synonymes : HPN / Maladie de MarchiafavaMicheli Encyclopédie Orphanet du Handicap. (n.d.). www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORP HA447.pdf 8. Fattizzo, B. et al., (2022). Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective. In Journal of Blood Medicine (Vol. 13, pp. 327– 335). Dove Medical Press Ltd. https://doi.org/10.2147/JBM.S339660 9. Kelly, R. J. et al., (2024) Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 143, Issue 12, pp. 1157-1166. https://doi.org/10.1182/blood.2023021762 10.1182/blood.2023021762 10. Ricklin, D. et al., (2017). The renaissance of complement therapeutics. In Nature Reviews Nephrology (Vol. 14, Issue 1, pp. 26–47). Nature Publishing Group. 11. Avis du Haut Conseil de la Santé Publique en vigueur.

]]> No 1 1 Dr Michael LOSCHI - Le point sur l'épidémiologie, la physiopathologie et le diagnostic de l'HPN full 0251b044-0161-4ec9-b0d9-b6b59b80764d https://share.transistor.fm/s/ea19e3b7 FR/UNB-P/0159 – Juillet 2024 Bibliographie : - Cançado, R. D., Araújo, A. da S., Sandes, A. F., Arrais, C., Lobo, C. L. de C., Figueiredo, M. S., Gualandro, S. F. M., Saad, S. T. O., & Costa, F. F. (2021). Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria. Hematology, Transfusion and Cell Therapy, 43(3), 341–348. https://doi.org/10.1016/j.htct.2020.06.006 - De Latour, R. P., Mary, J. Y., Salanoubat, C., Terriou, L., Etienne, G., Mohty, M., Roth, S., De Guibert, S., Maury, S., Cahn, J. Y., & Socie, G. (2008). Paroxysmal nocturnal hemoglobinuria: Natural history of disease subcategories. Blood, 112(8), 3099–3106. https://doi.org/10.1182/blood-2008-01-133918 - Haute Autorité de Santé. (2023). PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. - Höchsmann, B., Peffault de Latour, R., Hill, A., Röth, A., Devos, T., Patriquin, C. J., Chou, W. C., Jain, D., Zu, K., Wu, C., & Lee, J. W. (2023). Risk factors for thromboembolic events in patients with paroxysmal nocturnal hemoglobinuria (PNH): a nested case–control study in the International PNH Registry. Annals of Hematology, 102(11), 2979–2988. https://doi.org/10.1007/s00277-023-05402-3 - Kokoris, S. I., Gavriilaki, E., Miari, A., Travlou, Α., Kyriakou, E., Anagnostopoulos, A., & Grouzi, E. (2018). Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment. Hematology, 23(8), 558–566. https://doi.org/10.1080/10245332.2018.1444563 - Kulasekararaj, A. G., Brodsky, R. A., & Hill, A. (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 - Orphanet. (2019). Hémoglobinurie paroxystique nocturne. www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORPHA447.pdf - Parker, C., Omine, M., Richards, S., Nishimura, J. I., Bessler, M., Ware, R., Hillmen, P., Luzzatto, L., Young, N., Kinoshita, T., Rosse, W., & Socié, G. (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 - PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.).

]]> FR/UNB-P/0159 – Juillet 2024 Bibliographie : - Cançado, R. D., Araújo, A. da S., Sandes, A. F., Arrais, C., Lobo, C. L. de C., Figueiredo, M. S., Gualandro, S. F. M., Saad, S. T. O., & Costa, F. F. (2021). Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria. Hematology, Transfusion and Cell Therapy, 43(3), 341–348. https://doi.org/10.1016/j.htct.2020.06.006 - De Latour, R. P., Mary, J. Y., Salanoubat, C., Terriou, L., Etienne, G., Mohty, M., Roth, S., De Guibert, S., Maury, S., Cahn, J. Y., & Socie, G. (2008). Paroxysmal nocturnal hemoglobinuria: Natural history of disease subcategories. Blood, 112(8), 3099–3106. https://doi.org/10.1182/blood-2008-01-133918 - Haute Autorité de Santé. (2023). PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. - Höchsmann, B., Peffault de Latour, R., Hill, A., Röth, A., Devos, T., Patriquin, C. J., Chou, W. C., Jain, D., Zu, K., Wu, C., & Lee, J. W. (2023). Risk factors for thromboembolic events in patients with paroxysmal nocturnal hemoglobinuria (PNH): a nested case–control study in the International PNH Registry. Annals of Hematology, 102(11), 2979–2988. https://doi.org/10.1007/s00277-023-05402-3 - Kokoris, S. I., Gavriilaki, E., Miari, A., Travlou, Α., Kyriakou, E., Anagnostopoulos, A., & Grouzi, E. (2018). Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment. Hematology, 23(8), 558–566. https://doi.org/10.1080/10245332.2018.1444563 - Kulasekararaj, A. G., Brodsky, R. A., & Hill, A. (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 - Orphanet. (2019). Hémoglobinurie paroxystique nocturne. www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORPHA447.pdf - Parker, C., Omine, M., Richards, S., Nishimura, J. I., Bessler, M., Ware, R., Hillmen, P., Luzzatto, L., Young, N., Kinoshita, T., Rosse, W., & Socié, G. (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 - PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.).

]]> Mon, 05 Jan 2026 06:19:27 -0800 ALEXION ALEXION 473 FR/UNB-P/0159 – Juillet 2024 Bibliographie : - Cançado, R. D., Araújo, A. da S., Sandes, A. F., Arrais, C., Lobo, C. L. de C., Figueiredo, M. S., Gualandro, S. F. M., Saad, S. T. O., & Costa, F. F. (2021). Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria. Hematology, Transfusion and Cell Therapy, 43(3), 341–348. https://doi.org/10.1016/j.htct.2020.06.006 - De Latour, R. P., Mary, J. Y., Salanoubat, C., Terriou, L., Etienne, G., Mohty, M., Roth, S., De Guibert, S., Maury, S., Cahn, J. Y., & Socie, G. (2008). Paroxysmal nocturnal hemoglobinuria: Natural history of disease subcategories. Blood, 112(8), 3099–3106. https://doi.org/10.1182/blood-2008-01-133918 - Haute Autorité de Santé. (2023). PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. - Höchsmann, B., Peffault de Latour, R., Hill, A., Röth, A., Devos, T., Patriquin, C. J., Chou, W. C., Jain, D., Zu, K., Wu, C., & Lee, J. W. (2023). Risk factors for thromboembolic events in patients with paroxysmal nocturnal hemoglobinuria (PNH): a nested case–control study in the International PNH Registry. Annals of Hematology, 102(11), 2979–2988. https://doi.org/10.1007/s00277-023-05402-3 - Kokoris, S. I., Gavriilaki, E., Miari, A., Travlou, Α., Kyriakou, E., Anagnostopoulos, A., & Grouzi, E. (2018). Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment. Hematology, 23(8), 558–566. https://doi.org/10.1080/10245332.2018.1444563 - Kulasekararaj, A. G., Brodsky, R. A., & Hill, A. (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 - Orphanet. (2019). Hémoglobinurie paroxystique nocturne. www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORPHA447.pdf - Parker, C., Omine, M., Richards, S., Nishimura, J. I., Bessler, M., Ware, R., Hillmen, P., Luzzatto, L., Young, N., Kinoshita, T., Rosse, W., & Socié, G. (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 - PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.).

]]> No